The survey of research and development (R&D) in science and technology (S&T) covers the current status of R&D activities in S&T in Korea, and provides a basis for decision making regarding S&T policy. Continuous improvement of the survey is widely needed to present reliable national basic statistics. Therefore, the purpose of the study is two-fold: to introduce sampling survey method in industrial sector and to make statistical technique to deal with non-response data from industrial sector. To these ends, first, case studies of the United States and Japan are illustrated. A new sampling design for the R&D survey is proposed and implementing stratified random sampling scheme is suggested. Moreover, statistical analysis of the non-response data is dealt with. Based on several screening criteria, we develop a new imputation method suitable for the R&D survey and also provide more detailed implementation plan. Various solutions to a problem arising from non-response item are also presented. Finally, some implications of the results are discussed.