- 흰쥐에서 사염화 탄소로 유도된 간독성에 미치는 더위지기 추출물의 영향- I. 사염화탄소 독성유발 심화 수준에 대한 더위지기 추출물의 회복효과
- ㆍ 저자명
- 권진욱,이규승
- ㆍ 간행물명
- 환경독성학회지
- ㆍ 권/호정보
- 2002년|17권 2호|pp.161-174 (14 pages)
- ㆍ 발행정보
- 한국환경독성학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
To investigate effects of A. gmelini on the 14-day CCl$_4$induced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 5,000 mg/kg b.w. to administer orally once daily. Each concentration (5:5, 2:5 : 7.5, 1:9, CCl$_4$: olive oil v/v) of CCl$_4$was orally administered with 2.5 ml/kg b.w., During the experiment, halves of the rats were sacrificed every 7 day and hemanalysis was done. On the 7th day, hemanalysis showed following recovery values; AST 52.6∼61.4%, ALT 55.9∼86.1%, ALP 46.0∼70.9%, BUN 75.7∼100.0< %, TBIL 55.2∼96.1%, TCHO 38.0∼63.7%, and TG 55.2∼96.0%. On the 14th day, recovery values of each treatment were GOT 37.7∼43.1%, GPT 19.8∼45.9%, ALP 58.1∼95.9%, BUN 57.6∼100.0< %, TBIL 78.6∼100.0< %, TCHO 56.9∼100.0< %, and TG 10.0∼5l.2%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered by administration of A. gmelini extract.