Cooling characteristics of a parallel channel with protruding heat sources using convection and conduction heat transfer are studied numerically. A two-dimensional model has been developed for numerical prediction of transient, compressible, viscous, laminar flow, and conjugate heat transfer between parallel plates with uniform block heat sources. The finite volume method is used to solve the problem. The assembly consists of two channels formed by two covers and one printed circuit board which has three uniform heat source blocks. Six different cooling methods are considered to find out the most efficient cooling method in a given geometry and heat sources. The velocity and temperature fields of cooling medium, the temperature distribution along the block surface, and the maximum temperature in each block are obtained. The results are compared to examine the cooling characteristics of the different cooling methods.