- 화장품중 살균ㆍ보존제의 동시분리 및 정량
- Simultaneous HPLC Determination of Preservatives in Cosmetics
- ㆍ 저자명
- 양성준,김영옥,손경훈,이정표,정래석,양원준,백옥진,이현경,최상숙
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 2002년|46권 4호|pp.231-236 (6 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
A high-performance liquid chromatographic method for the simultaneous quantitative analysis of methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP) and imidazolidinyl urea(IU) or diazolidinyl urea(DU) in cosmetics was studied by using a cyano-propyl column and 0.05M hexanesulfonic acid at 228 nm. Calibration curves were found to be linear in the 60-1000 $mu extrm{g}$/mL range (parabens), 100-1,250 $mu extrm{g}$/mL range (IU) and the 120-2000 $mu extrm{g}$/mL range (DU). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic method to a commercial cosmetic cream. The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (0.46-2.71%) was excellent for all compounds.