The failure probability of wheel beyond 10$^$7/ cycles is achieved by the strengths-stress interference model for the evaluation of fatigue strength and reliability in the wheel, From plane bending fatigue test results, the fatigue life (N$\_$f/) for the smooth and 200㎛ holed specimens can be represented as $sigma$$\_$a/ = 1326N$\_$f/$^$-0.10/ and $sigma$$\_$a/ = 2894N$\_$f/$^$-0.18/. Respectively, fatigue strength of the wheel at beyond 10$^$7/cycles was about 332 MPa. And, the fatigue strength for the specimen with a micro hole (d=200㎛) which simulated an inclusion on the wheel surface was about 235 MPa. Thus, a micro hole (d=200㎛) caused about 30% reduction of fatigue strength of the specimen. The failure probabilities for the smooth and micro-holed specimens, derived from the strength-stress interference model, are 0.0148% and 13.05%, respectively. The current finding suggests that at least 200 ㎛ sized inclusion, which might be produced during manufacturing process, will cause a critical effect on integrity of the railway vehicle.