The effect of shear coupled with axial force variation on the inelastic seismic behaviour of reinforced concrete bridge piers is investigated in this paper. For this purpose, a hysteretic axial-shear interaction model was developed and implemented in a nonlinear finite element analysis program. Thus, flexure-shear-axial interaction is simulated under variable amplitude reversed actions. Comparative studies for shear-dominated reinforced concrete columns indicated that a conventional FE model based on flexure-axial interaction only gave wholly inadequate results and was therefore incapable of predicting the behaviour of such members. Analysis of a reinforced concrete bridge damaged during the Northridge (California 1994) earthquake demonstrated the importance of shear modelling. The contribution of shear deformation to total displacement was considerable, leading to increased ductility demand. Moreover, the effect of shear with axial force variation can significantly affect strength, stiffness and energy dissipation capacity of reinforced concrete members. It is concluded that flexure-shear-axial interaction should be taken into account in assessing the behaviour of reinforced concrete bridge columns, especially in the presence of high vertical ground motion.