In this study, the analysis of high-speed vehicle-bridge interactions by a simplified 3-dimensional finite element model is performed. Since railroads are constructed mostly as double tracks, there exists eccentricity between the vehicle axle and the neutral axis of cross section of a railway bridge. Therefore, for the more efficient and accurate vehicle-bridge interaction analysis, the analysis model should include the eccentricity of axle loads and the effect of torsional forces acting on the bridge. The investigation into the influences of eccentricity of the vehicle axle loads and vehicle speed on vehicle-bridge interactions are carried out for two cases. In the first case, only one train moves on its track and in the other case, two trains move respectively on their tracks in the opposite direction. From the analysis results of an existing bridge, the efficiency and capability of the simplified 3-dimensional model for practical application can be also verified.