A control algorithm combining viscous and non-linear Reid damping mechanisms has been recently proposed by the authors to command active friction dampers. In this paper, friction dampers and the proposed algorithm are applied to control the seismic responses of a nonlinear 20-story building. Piezoelectric stack actuators are used to implement the control algorithm. The capacity of each damper is determined by the practical size of piezoelectric actuators and the availability of power supply. The saturation effect of the actuators on the building responses is investigated. To minimize the peak story drift ratio or floor acceleration of the building structure, a practical sequential procedure is developed to sub-optimally place the dampers on various floors. The effectiveness of active friction dampers and the efficiency of the proposed sequential procedure are verified by subjecting the building structure to four earthquakes of various intensities. The performance of 80 dampers and 137 dampers installed on the structure is evaluated according to 5 criteria. Numerical simulations indicated that the proposed control algorithm effectively reduces the seismic responses of the uncontrolled 20-story building, such as inelastic deformation. The sub-optimal placement of dampers based on peak acceleration outperforms that based on peak drift ratio for structures subjected to near-fault ground motions. Saturation of piezoelectric actuators has adverse effect on floor acceleration.