This paper describes a simple method for evaluating the design wind loads for the structural frames of circular flat roofs with long spans. The dynamic response of several roof models were numerically analyzed in the time domain as well as in the frequency domain by using wind pressure data obtained from a wind tunnel experiment. The instantaneous displacement and bending moment of the roof were computed, and the maximum load effects were evaluated. The results indicate that the wind-induced oscillation of the roof is generally dominated by the first mode and the gust effect factor approach can be applied to the evaluation of the maximum load effects. That is, the design wind load can be represented by the time-averaged wind pressure multiplied by the gust effect factor for the first mode. Based on the experimental results for the first modal force, an empirical formula for the gust effect factor is provided as a function of the geometric and structural parameters of the roof and the turbulence intensity of the approach flow. The equivalent design pressure coefficients, which reproduce the maximum load effects, are also discussed. A simplified model of the pressure coefficient distribution is presented.