A new titanium based alloy, Ti-10Ta-10Nb, has designed to examine the improved mechanical properties and biocompatibility. A specimen of titanium alloy was melted in a consumable vacuum arc furnace and homogenized at $1050^{circ}C$ for 24 h. The effect of hot rolling on microstructure was estimated after rolling at $400^{circ}C$ and $800^{circ}C$ respectively. Surface of melted alloy by consumable vacuum arc melting was consisted of rough surface and it was changed to sound surface by coating of $ZrO_2$ slurry on copper mold surface. The hardness of Ti-10Ta-10Nb alloy increased with the amount of${alpha}+{eta}$ phase. Ti-10Ta-10Nb alloy showed $Widmanst{"{a}}ten$ structure by hot rolling at $800^{circ}C$ and in the rolling ${eta}-region$ was negligible effects on microstructure refining.