The purpose of this study was to the relationship between powerlessness, self-efficacy and quality of life in hemodialysis patients. The subjects were compromised of 198 hemodialysis patients from Pusan, Kyung-Sang Namdo and Kyung-Sang Bukdo 6 hemodialysis clinics. Data were collected by questionnaires from Sep. 19 to Oct. 27, 2001. The instrument used for study were the Powerlessness Behavioral Assessment Tool(Miller, 1983) and self-efficacy developed by Kim, Ju-Hyun(1995) and quality of life developed by Kim, Ok-Soo(1993). Collected data were analyzed by frequency, percentage, mean, standard deviation, t-test, ANOVA, Scheffe test, pearson correlation. The results were as follows. 1. The mean score of powerlessness was $52.41{pm}6.93$, mean mark $3.28{pm}0.43$, and the mea score of self-efficacy was $45.44{pm}7.75$, mean mark $2.87{pm}0.49$, and the mea score of quality of life was $121.27{pm}23.81$, mean mark $2.96{pm}0.58$. 2. There were significant differences in the level of powerlessness according to sex(t=2.148, p=.033), occupation(t=3.682, p=.000), economic status(F=3.094, p=.048), experience of hospitalization (t=-2.002, p=.047). 3. There were significant differences in the level of self-efficacy according to age(F=3.271, p=.013), economic status (F=5.759, p=.004), religion(F=2.667, p=.048), hemodialysis period(F=2.991, p=.032), hemodialysis frequency(t=9.045, p=.003), experience of hospitalization (t=4.40, p=.037). 4. There were significant differences in the level of quality of life according to occupation(t=3.796, p=.053), economic status(F=11.478, p=.000), hemodialysis frequency(t=7.573, p=.006). 5. There were significant negative correlation between powerlessness and self-efficacy (r=- .401, p<.001) powerlessness and quality of life(r=- .562, p<.001). There were significant positive correlation between self-efficacy and quality of life(r= .512, p<.001).