The present work concerns the optimal design for injection molding processes by using the design of experiments (DOE) and numerical analysis. The DOE approaches is planned to be able to consider two-way interaction, and have been applied progressively for both mold design and process design. Numerical analyses have been carried out as a design of experiments for mold parameters such as runner specifications and cooling channel configurations. In order to determine optimal process parameters, experiments have been performed for various process conditions with the DOE scheduling. As a result, the quality and productivity of the product have been improved, and the proposed approach can be successfully reflected on the industrial injection molding process of precision electronics parts.