This paper represents an investigation of the vehicle-to-vehicle distance control system using Hardware-in-the-Loop Simulation(HiLS). Control logic is primarily developed and tested with a specially equipped test vehicle. Establishment of an efficient and low cost development tool is a very important issue, and test vehicle approach is costly and time consuming. HiLS method is useful in the investigation of driver assistance and active safety systems. The HiLS system consists of a stepper motor for throttle control, a hydraulic brake system with an electronic vacuum booster, an electronic controller unit, a data logging computer which are used to save vehicle states and signals of actuator through a CAN and a simulation computer using mathematical vehicle model. Adaptation of a CAN instead of RS-232 Serial Interface for communication is a trend in the automotive industry. Since this environment is the same as a test vehicle, a control logic verified in laboratory can be easily transferred to a test vehicle.