In this paper, we design and implement a real-time route guidance system(RGS) in large-scale networks. Coupled with the well-known mathematical routing algorithms, we devise an RGS for knowledge aquisition and self-learning ability within the framework of the expert system. Through off-line construction of database, on-line treatment of unexpected traffic accidents, etc., the developed RGS can provide drivers with good quality real-time routing information. The practical effectiveness of the proposed system is demonstrated in terms of response time and route appropriateness.