Objective : We aimed to identify the inhibitory effects of SocheongRyoungTang on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells. This experiment was designed to investigate the effect of SoCheongRyongTang(SCRT) on Antiallergy. Materials and Methods : We measured the cytotoxic activity for cytokines transcript expression, production of $IL-1{eta},;IL-4,;IL-6,;IL-10,;IFN-{gamma},;TNF-{alpha},;TGF-{eta}$ proliferation of B cell in anti-CD40mAb plus rIL-4 plus HRF stimulated murine splenic B cells and histamine in anti-CD40mAb plus rIL-4 plus HRF stimulated mast cells. Results : 1. SCRT increased the gene synthesis of $IFN-{gamma}(m-RNA)$, the appearance of IL-10, $IFN-{gamma}$. 2. SCRT decreased the gene synthesis of $IL-l{eta},;IL-4,;TGF-{eta}(m-RNA)$ and the appearance of $IL-l{eta},;IL-4,;TGF-{eta},;IgE$ significantly. Conclusion : SCRT decreased the proliferation of B cell significantly. According to the above results, it is suggested that SCRT extract might be usefully applied for prevention and treatment of Allergic disease.