Objective : This study is to examine the interrelationship between Infertility with hypothalamic-pituitary gland disorders and Face temperature by D.I.T.I. Methods : Sample group is the 50 women who were diagnosed as P.C.O.S. or FSH,LH trouble or hyper-prolactinemia or anovulation or oligo-ovulation. Control group is the 50 women who have not P.C.O.S. & FSH.LH trouble & hyper-prolactinemia & anovulation or oligo-ovulation, who have normal menstural cycle and success in pregnancy after treatment. Both group came at Conmaul Oriental Hospital Infertility Center, Seoul, Korea, from May, 2001 to Jan., 2003. They selected at random. We checked temperature of ${ulcorner}S17{lrcorner};{ulcorner}SI18{lrcorner};{ulcorner}TE17{lrcorner};{ulcorner}HN-3{lrcorner}$ and gained differences of Rt. check point and Lt. check point, and then compared mean ${Delta}T$ of sample group with that of control group. Conclusion : We gained results that mean ${Delta}T$ of sample group is larger than that of control group at all check points. (p=0.000)