Pernicious anemia is a pathologic state due to lack of Vit.B12 or folic acid. Pernicious anemia is due to metabolic disorder including poor absorption of stomach through gastroectomy. We experienced a 76 year old male patient diagnosed as pernicious anemia for perfomed total gastroectomy. Herbal medicine that we had was mainly treated and several remarkable changes have been showed. This is a clinical report of that patient.