The Effects and processing methods of Rhei Rhizoma from Donguibogam and Chejungsinpyeon were studied, Through the study, we found 21 kinds of processing method of Rhei Rhizoma in Donguibogam and Chejungsinpyeon, Processing methods used in Donguibogam and Chejungsinpyeon were effective from reducing side effects of Rhei Rhizoma, and were safe in clinical application, the aims of processing methods of Rhie Rhizoma were safer application by reducing poisonous character, and increase the range of clinical application by useing 21 kinds of processing methods.