The purpose of study was to investigate the effect of carbon dioxide laser on demineralization inhibition and rehardening of primary tooth enamel according to its power and irradiation time. 2mm diameter circle on the primary enamel surface was irradiated by defocused $10.6{mu}m$ superpulse carbon dioxide laser at 6 Watt 2 seconds or at 3 Watt 8 seconds, before or after demineralization by Coca-Cola for 24 hours. Enamel surface change was measured by the Diagnodent. The results were analyzed with the former study results of 3 Watt 4 seconds and 6 Watt and 4 seconds. Diagnodent scores increased significantly after demineralization of irradiated enamel at 6W 2s or 3W 8s (P<0.05). Among the four groups, only 6W 4s group showed obvious demineralization inhibition effect. Diagnodent scores reduced significantly after 6W 2s or 3W 8s irradiation of demineralized enamel(P<0.05). Among the four groups, 6W 4s showed nearly complete rehardening effect, and the other groups showed partial effect. Tooth discoloration only occurred at 6W 4s. It seemed that caries inhibition and tooth discoloration depend on laser power more than total irradiation energy.