This study was carried out to compare the bioavailability of $Ceclex^{(R)}$ SR TAB (test drug, cefaclor 375 mg/Tablet) with that of Ceclor $MR^{(R)}$ SR IAB (reference drug) and to estimate the pharmacokinetic parameters of cefaclor in healthy Korean volunteers. The bioavailability was examined on 24 healthy volunteers who received a single dose (375 mg) of each drug in the fasting state in a randomized balanced 2-way crossover design. After dosing, blood samples were collected for a period of 7 hours. Plasma concentrations of cefaclor were determined using HPLC with UV detection. The pharmacokinetic parameters $(AUC_{0-7h},;C_{max},;T_{max},;AUC_{inf},;K_e,;t_{1/2},;V_d/F,;and;CL/F)$ were calculated with non-compartmental pharmacokinetic analysis. The ANOVA test was utilized for the statistical analysis of the $T_{max}$, log-transformed $AUC_{0-7h$}$, log-transformed $C_{max},;t_{1/2},;V_d/F$, and $CL/F$. The ratios of geometric means of $AUC_{0-7h};and;C_{max}$ between test drug End reference drug were $95.67\%;(8.55;vs;8.18{mu}g{cdot}hr/ml);and;103.86\%;(2.85;vs;2.96{mu}g/ml)$, respectively. The $T_{max}$ of test drug and reference drug was $2.56pm0.15;and;2.23pm0.13;hrs,;respectively.;The;90\%$ confidence intervals of mean difference of logarithmic transformed $AUC_{0-7h};and;C_{max}$ were log0.90-log1.04 and log0.91-log1.13, respectively. It shows that the bioavailability of test drug is equivalent with that of reference drug.