This study was to investigate the effect of 10th weeks Exercise of Different Intensity on the activation of antioxidation enzyme and lipid peroxidation. 15 subjects were divided into the 65$\%$ running exercise(EG; 5), 85$\%$ running exercise(EG: 5), and the control(CG: 5) groups. The exercise group had 10 week of running exercise 4 times a week with ACSM(1995) protocol, 65$\%$ of HRmax from the beginning to 5th week, 85$\%$ of HRmax from 6th to 10th week. The subjects had 60 min exercise for each day. After extracting the blood sample, the activation of antioxidation enzyme and lipid peroxidation were compared between the groups. The one way ANOVA was conducted about pretest, 5th week, and 10th week of the subject data. The results obtained from this study were as follows; 1. The 65$\%$ exercise group showed the significantly greater increase in the activation of SOD after 10 weeks for the rest and all-out exercise. (p < .05). 2. The 65$\%$ exercise group displayed the significantly higher increase in the activation of CAT after 10th weeks for the rest exercise. (p < .05). 3. The 65$\%$ exercise group had the significantly greater decrease in the activation of MDA after 10 weeks for the all-out exercise. (p < .05).