In this study, the structural optimal design was applied to the girder of over head crane. The optimization was carried out using ANSYS code fur the deadweight of girder, especially focused on the thickness of its upper, lower, reinforced and side plates. The weight could be reduced up to around 15% with constraints of its deformation, stress and buckling strength. The structural safety was also verified by the buckling analysis of its panel structure. It might be thought to be very useful to design the conventional structures fur the weight save through the structural optimization. The objective function and restricted function were estimated by the orthogonal array, and the sensitivity analysis of design variable fur that was operated.