During the operation, fatigue failures and cracks of duct plate due to excessive duct vibration occurred in a fan-duct system of fossil fueled boilers. We measured static pressure variation (pressure pulsation) in the outlet, and also measured vibration at the outlet duct of a centrifugal fan. It was found that strong pressure pulsation caused by the inlet vortex occurred in inlet vane of centrifugal fan in the middle range of vane opening. Thus, excessive duct vibration is caused by strong pressure pulsation. In this Paper, it is shown that the frequency and amplitude of pressure pulsation depend mainly on vane opening and are compared with duct vibration. Also, effective solution for reducing pressure pulsation and vibration are presented.