Control algorithms of an air handling unit by using the mixing box plenum pressures were developed and verified by experiments. Control algorithms developed for this study were the setpoint algorithms for the outdoor damper position, the outdoor/fixed plenum pressure, and the return/exhaust plenum pressure. The outdoor/fixed plenum pressure setpoint was used to control the bypass damper position, and the return/exhaust plenum pressure setpoint was used to control the return fan speed. Experimental results showed the good control of the required outdoor air demand. Therefore, setpoint algorithms developed for this study may effectively be applied for the control of the VAV air handling unit.