Vibration analysis using component mode synthesis method was carried out to identify that to some extent each component contributed to the whole vibration of a powertrain consisting of several components. This analysis helped decide the component to be modified to reduce the powertrain weight, without degrading its current vibration characteristics. As a result, a cylinder block was chosen as a redesign object. Topology optimization analysis was performed to design the topology of the cylinder block whose flange connected with the transmission was chosen to be the design domain. After all, a new prototype of cylinder block was manufactured based on the analysis results for the verification experiment. It was confirmed from the analytical and experimental results that u optimally designed cylinder block had an advantage over the current one in the powertrain weight, with the powertrain vibration characteristics improved slightly.