The vitality of a main street is essential to get the urbanity of the urban residential estates. The purpose of this study is to analyze the relationship between the vitality of a main street and street land uses in the residential estate. The outcomes of this study are as follows: first, the street land uses have influence on the vitality of a main street; the main streets with the small commercial and business facilities are more vitalized than those with the boundary wall of the residential building or the buffer zone. Second, the number of shops in street has positive influence on the vitality of a main street. Third, the vitality of a main street is effected by the entrance of apartment site.