An experimental investigation on the flow pattern and pressure drop was carried out for both an adiabatic and a diabatic two-phase flow in a horizontal tube with pure refrigerants R134a and R123 and their mixtures as test fluids. The observed flow patterns were compared to the flow pattern map of Kattan et al., which predicted well the present data over the entire regions of mass velocity in this study. The measured frictional pressure drop in the adiabatic experiments increased with an increase in vapor quality and mass velocity These data were compared to various correlations proposed in the past for the frictional pressure drop. The Chisholm correlation underpredicted the present data both for pure fluids and their mixtures in the entire mass velocity range of 150 to 600 kg/m$^2$s covered in the measurements, white the Friedel correlation was found to overpredict the present data in the stratified and stratified-wavy flow region, and to underpredict in the annular flow region.