The applicabilities and validities of two methodologies fur the prediction of THM (trihalomethane) formation in a water pipeline system were proposed and discussed. One is the multiple regression technique and the other is an artificial neural network technique. There are many factors which influence water quality, especially THMs formations in water pipeline systems. In this study, the prediction models of THM formation in water pipeline systems are developed based on the independent variables proposed by American Water Works Association(AWWA). Multiple linear/nonlinear regression models are estimated and three layer feed-forward artificial neural networks have been used to predict the THM formation in a water pipeline system. Input parameters of the models consist of organic compounds measured in water pipeline systems such as TOC, DOC and UV254. Also, the reaction time to each measuring site along pipeline is used as input parameter calculated by a hydraulic analysis. Using these variables as model parameters, four models are developed. And the predicted results from the four developed models are compared statistically to the measured THMs data set. It is shown that the artificial neural network approaches are much superior to the conventional regression approaches and that the developed models by neural network can be used more efficiently and reproduce more accurately the THMs formation in water pipeline systems, than the conventional regression methods proposed by AWWA.