The objective in this paper is to develope the e-Supply Chain Management System and applied for the Manufacturing. A Manufacturing that is consider to be world class recognize that its ability to complete in the marketplace depends on developing e-SCM System that is properly align with its mission of serving the customer. This paper investigated the relationship between e-SCM and performance in manufacturing. A stratified random sample was collected from the Federation of Korea Industries. Conclusively, e-SCM is important factor between source factors (environmental dynamic, Leadership) and manufacturing performance. e-SCM is significantly related to Quality, Flexibility, Delivery, and Cost.