The suitability of high-order accurate, centered and upwind-biased compact difference schemes for large eddy simulation is evaluated by a spectral, static error analysis. To investigate the effect of numerical dissipation on LES solutions, power spectra of discretization errors are evaluated for isotropic turbulence models in both continuous and discrete wavevector spaces. Contrary to the common belief, the aliasing errors from upwind-biased schemes are larger than those from comparable non-dissipative schemes. However, this result is the direct consequence of the definition of the power spectral density of the aliasing error, which poses the limitation of the static error analysis for upwind schemes.