This paper presents a serial communication based fault diagnosis scheme for a brushless DC (BLDC) motor using parameter estimation and Bayes classifier. The presented scheme consists of a smart network board, and a fault detection and isolation (FDI) master. The smart network board is installed near the BLDC motor drive system to acquire motor data and transmit motor data to the FDI-master via serial communication channel. The FDI-master estimates BLDC motor resistance to detect symptom of faults, and assign symptom to fault type using Bayes classifier. In this scheme, since communication time delay has a serious effect on performance, periodic and fixed communication protocol is designed. Hence, the delay time is priory known. By experiment result, presented scheme was verified.