An inverse radiation analysis is presented for the estimation of the boundary emissivities for an absorbing, emitting, and scattering media with diffusely emitting and reflecting opaque boundaries. The finite-volume method is employed to solve the radiative transfer equation for a two-dimensional irregular geometry. A hybrid genetic algorithm is proposed for improving the efficiency of the genetic algorithm and reducing the effects of genetic parameters on the performance of the genetic algorithm. After verifying the performance of the proposed hybrid genetic algorithm, it is applied to inverse radiation analysis in estimating the wall emissivities in a two-dimensional irregular medium when the measured temperatures are given at only four data positions. The effect of measurement errors on the estimation accuracy is examined.