An experiment study on pressure drop was carried out for both an adiabatic and a diabatic two-phase flow with pure refrigerants R134a and Rl23 and their mixtures as test fluids in a uniformly heated horizontal tube. The frictional pressure drop during flow boiling is predicted by using two models; the homogeneous model that assumes equal phase velocity and the separate flow model that allows a slip velocity between two phases. The measured frictional pressure drop was compared to a few available correlations. Homogeneous model considerally underpredicted the present data for mixture as well as pure component in the entire mass velocity ranges employed in the present study, while Friedel correlation was found to satisfactorily correlate the frictional pressure drop data as compared to other correlation.