We proposed an optimum PID controller design method of the Smith Predictor It can be applied to various processes. The real process is approximated via the second order plus time delay model (SOPTD) whose parameters are specified through a model reduction algorithm. We already proposed a new model reduction method that considered four point in the Nyquist curve to reduced the steady state error between the real process model and the reduced model using the gradient decent method and the genetic algorithms. In addition, the Smith predictor is used to compensate time delay of the real process model. In this paper, the new optimum parameter tuning algorithm for PID controller of the Smith Predictor is proposed through ITAE as performance index. The Simulation results show the validity and improvement of performance for various processes.