A CFD simulation technique has been developed to handle the unsteady body motion with large amplitude by use of overlapping multi-block grid system. The three-dimensional, viscous and incompressible flow around body is investigated by solving the Navier-Stokes equations, and the motion of body is represented by moving effect of the grid system. Composite grid system is employed in order to deal with both the body motion with large amplitude and the condition of numerical wave maker in convenience at the same time. The governing equations, Navier-Stokes (N-S) and continuity equations, are discretized by a finite volume method, in the framework of an O-H type boundary-fitted grid system (inner grid system including test model) and a rectangular grid system (outer grid system including simulation equipments for generation of wave environments). If this study, several flow configurations, such as an oscillating cylinder with large KC number, are studied in order to predict and evaluate the hydrodynamic forces. Furthermore, the motion simulation of a Series 60 model advancing in a uniform flow under the condition of enforced roll motion of angle 20$^{circ}$ is performed in the developed numerical wave tank.