For the development of new anticonvulsive agents, GABAmimetics such as nipecotic acid, isonipecotic acid, ${gamma}-aminobutyric$ acid (GABA), ${gamma}-vinyl$ GABA (vigabatrin) and valproic acid were covalently coupled through an ester bond by a two-carbon linker chain as potential prodrugs and evaluated for their anticonvulsive activities.