This paper proposes an efficient mechanism design system of multi-stage gear drives including not only parallel shaft gears but also non-parallel gears such as bevel and worm gear drives. The system automatically generates three dimensional structures of specification-adjusted mechanisms, and shows the sorted list of the mechanisms according to the evaluation result by using a fuzzy expert system. The list can be used as reliable candidates of the spatial mechanism structures of multi-stage gear drives. Thus, it is expected that the system can increase the efficiency of design and cut off the expenses of preliminary design considerably.