The large eddy simulation based Fire Dynamics Simulator was utilized to investigate the effects of the size of an opening on smoke removal performance for the three smoke control systems-ventilation purge, and extraction. Three different opening sizes, $r_A$=1, 2, and 3 were investigated while the flow rate remained 0.75 $m^3/s$ at the inlet or outlet depending on the systems. Increase of the opening size did not give a significant difference in the smoke removal rate for the three smoke control systems, though the increasing opening size slightly improved smoke removal. The extraction system was shown the best smoke control system, and the purge system yielded low performance compared to the other two systems for all the different opening sizes.