This article proposes an integrated systems engineering and safety analysis model for safety-critical systems development. A methodology in system design for safety is considered during the early phase of the development life cycle of systems engineering process. The evolution of the design automation technology has enabled engineers to perform the model-based systems engineering. A Computer-Aided Systems Engineering(CASE) tool, CORE, is utilized to integrate the systems engineering model with a system safety analysis model. The results of the functional analysis phase can drive the analysis of the system safety. An example of Communications-Based Train Control(CBTC) system for an Automated Guided Transit(AGT) system demonstrated an application of the integrated model.