A simulated control group pretest-posttest design was used to investigate the effects of a health promotion education program on knowledge, attitude, and self-efficacy in sexuality, drinking, and smoking among college women. The subjects included 17 women in the experimental group, and twenty in the control group. This program was carried out for a total of four sessions, two hours per session once a week. The results were as follows； 1) Knowledge on sexuality, drinking, and smoking increased significantly in the experimental group compared to the control group (U＝66.50, p＝.001 ； U＝23.50, p＝.000； U＝29.50, p＝.000). 2) For attitude, only the attitude to drinking showed a significant difference between the two groups (U＝76.00, p＝.004). 3) For self-efficacy, only self-efficacy on drinking showed a significant difference between the two groups (U＝55.00, p＝.000). In conclusion, the health promotion program for college women increased their knowledge on sexuality, drinking, and smoking. This program affected their attitude and self-efficacy towards moderation in drinking. A even more appropriate education program on sexuality, drinking, and smoking for college women could be developed using this program by addressing the limitations in this study and repeating the study with a more varied sample.