Recent studies indicate potential links between various psychosocial factors and work-related musculoskeletal disorders (WMSDs). In this research, the effects of job stressors on the WMSDs symptoms were investigated using questionnaire in the largest automotive company in Korea. It was found that perception of workload, over time and shift work, and working using powered hand tools were significant factors for the symptoms of WMSDs, along with smoking habit, periodic exercise, and interpersonal relationship. Practical applications of this research include practitioners taking into account psychosocial work factors and job stress in their efforts to reduce and control WMSDs.