Fatigue is a universally common word. The subject has been studied in different disciplines, but the basic concept of the term still remains unidentified. It becomes especially important for the medical communications between nurses and clients. Based on the framework outlined by Walker and Avant (1995), this analysis attempts to clarify and examine the symptoms of fatigue. The attributes of fatigue identified in this paper were exhaustion, weighted psychological burden, shortage in capacity or lack of energy, shortage incapacity(motivation and excitement), and imbalance of energy. Therefore, the definition of fatigue refers to a subjective feeling from various internal or external stresses. The consequences of fatigue bring reduced capacity and imbalance of energy. The symptoms show a homeostatic disability or shortage of capacity (physical, psychological, environmental and physiological factors). A precise understanding of "fatigue" will be utilized in defining the causes and measuring outcomes. Also, it will enhance the effective medical communications with client s and nurses. In conclusion, more work is needed to develop objective measurement and effect ivenursing intervention.