HGJT has been used for the treatment of general weakness, digestive organ disease and so on. This study was carried out for the purpose of knowing the inhibitory effect on the Type I hypersensitivity and Inflammatory reactions of Hwanggigunjungtang(HGJT). The reasults were obtained as follows: HGJT(0.1. 0.5. 1, 2mg/g) concentration of dependently inhibited compound48/80 induced anaphylaxis reaction in mice. HGJT(2mg/g) also inhibited permeability of evans blue into peritoneal cavity in mice. HGJT reduced IgE, CRP. WBC and Platelets on egg albumin induced hypersensitivity. But serum NO was grown. According to above results, HGJT may be beneficial in the type I hypersensitivity and Inflammatory reactions by inhibition of histamine release from mast cells.