In order to consider the modified seismic response of framed structures in the presence of masonry infills, proper models have to be formulated. Because of the complexity of the problem, a careful definition of a diagonal pin-jointed strut, able to represent the horizontal force-interstorey displacement cyclic law of the actual infill, may be a solution. In this connection the present paper shows a generalized criterion for the determination of the ideal cross-section of the strut mentioned before. The procedure is based on the equivalence between the lateral stiffness of the actual infilled frame scheme during the conventional elastic stage of the response and the lateral stiffness of the same frame stiffened by a strut at the same stage. Unlike the usual empirical approaches available in the literature, the proposed technique involves the axial stiffness of the columns of the frame more than their flexural stiffness. Further, the influence of the bidimensional behaviour of the infill is stressed and, consequently, the dependence of the dimensions of the equivalent pin-jointed strut on the Poisson ratio of the material constituting the infill is also shown. The proposed approach is extended to the case of infills with openings, which is very common in practical applications.