A long suspension bridge is often located within a unique wind environment, and strong winds at the site seldom attack the bridge at a right angle to its long axis. This paper thus investigates the buffeting response of long suspension bridges to skew winds. The conventional buffeting analysis in the frequency domain is first improved to take into account skew winds based on the quasi-steady theory and the oblique strip theory in conjunction with the finite element method and the pseudo-excitation method. The aerodynamic coefficients and flutter derivatives of the Tsing Ma suspension bridge deck under skew winds, which are required in the improved buffeting analysis, are then measured in a wind tunnel using specially designed test rigs. The field measurement data, which were recorded during Typhoon Sam in 1999 by the Wind And Structural Health Monitoring System (WASHMS) installed on the Tsing Ma Bridge, are analyzed to obtain both wind characteristics and buffeting responses. Finally, the field measured buffeting responses of the Tsing Ma Bridge are compared with those from the computer simulation using the improved method and the aerodynamic coefficients and flutter derivatives measured under skew winds. The comparison is found satisfactory in general.