In the past decades, much effort has been made towards the study of single-mode-based vibration controls with dynamic energy absorbers such as single or multiple Tuned Mass Dampers(TMDs). With the increase of bridge span length and the tendency of the bridge cross-section being more slender and streamlined, multi-mode coupled vibrations as well as their controls have become very important for large bridges susceptible to strong winds. As a simple but effective device, the TMD system especially the semi-active one has become a promising option for such coupled vibration controls. However, despite various studies of optimal controls of single-mode-based vibrations with TMDs, research on the corresponding controls of the multi-mode coupled vibrations is very rare so far. For the development of a semi-active control strategy to suppress the multi-mode coupled vibrations, a comprehensive parametric analysis on the optimal variables of this control is substantial. In the present study, a multi-mode control strategy named "three-row" TMD system is discussed and the general numerical equations are developed at first. Then a parametric study on the optimal control variables for the "three-row" TMD system is conducted for a prototype Humen Suspension Bridge, through which some useful information and a better understanding of the optimal control variables to suppress the coupled vibrations are obtained. This information lays a foundation for the design of semi-active control.