The End-milling has been widely used in the industrial world because it is effective to cutting working with various shape. Recently the end-milling is demanded the high-precise technique with good surface roughness and rapid manufacturing time for precision machine and electronic elements. The cutting working of end-milling such as, cutting direction, revolution of spindle, feed rate and depth of cut have an effect on optimum surface roughness. This study was carried out to decide the working condition for optimum surface roughness and rapid manufacturing time by design of experiment and ANOVA. From the results of this study, the optimum working condition for end milling is upward cutting in cutting direction, 600rpm in revolution of spindle, 240mm/mm in feed rate, 2mm in axial depth of cut and 0 25mm in radial depth of cut. The design of experiment has become an useful method to select optimum working condition mend-milling.