Cam mechanism is a machine part frequently used in machinery. Specially, conjugate cam mechanism is very suitable for the high speed working and the heavy power translation. Then a conjugate cam mechanism need high precision for the relations between cam profiles and follower rollers. So, its design and manufacturing are very difficult. Thus, this study is a branch of exclusive CAM systems for design and NC machining of conjugate earn mechanism based on a master plate earn profile in order to exchange an old plate cam mechanism to a new conjugate earn mechanism. For the design of the other cam profile by using a master cam profile, some calculation processes were used by vector summation methods, from master cam profile data to the center data of master follower, from the center data of master follower to the center data of the other follower considered in link mechanism, and offsetting in the center direction of base circle of the other cam from the center data of the other follower. Finally, a sample conjugate cam was selected and machined m order to prove the contents of this study.