The multiple steam generator tube rupture (SGTR) event scenario with available safety systems was experimentally and analytically evaluated. The experiment was conducted on the large scaled test facility to simulate the multiple SGTR event and investigate the effectiveness of operator actions. As a result, it indicated that the opening of pressurizer power operated relief valve was significantly effective in quickly terminating the primary-to-secondary break flow even for the 6.5 tubes rupture. In the analysis, the recent version of RELAP5 code was assessed with the test data. It indicated that the calculations agreed well with the measured data and that the plant responses such as the water level and relief valve cycling in the damaged steam generator were reasonably predicted. Finally, sensitivity study on the number of ruptured tubes up to 10 tubes was performed to investigate the coolant release into atmosphere. It indicated that the integrated steam mass released was not significantly varied with the number of ruptured tubes although the damaged steam generator was overfilled for more than 3 tubes rupture. These findings are expected to provide useful information in understanding and evaluating the plant ability to mitigate the consequence of multiple SGTR event.