Purpose: This research was for checking the effect of meridian massage on the reduction of pain and subjective symptoms of myofascial pain syndrome. Method: The method of the research was interruptive time series design. The research objects are 25 hospital workers with myofascial pain syndrome at B hospital in Busan from July 22, 2002 to August 18, 2002. SPSS Win 10.0 was used for data analysis, paired t-test and repeated measures ANOVA for hypothesis test. Result: The recipients of meridian massage felt less pain than before(F=12.587, p=.000). The recipients of meridian massage felt less often than before (F=6.705, p=.001). The recipients of meridian massage got lower score on subjective symptoms of myofascial pain than before(F=12.857, p=.000). The recipients of meridian massage had lower blood pressure than before(systolic blood pressure; t=4.697, p=.000, diastolic blood pressure; t=3.426, p=.002). The recipients of meridian massage did not get the lower number of pulse than before(t=0.33, p=.744). Conclusion: The above results show that meridian massage is effective on the reduction of pain and subjective symptoms of myofascial pain syndrome and makes stable the blood pressure. Therefore meridian massage can be apply as the effective intervention for the reduction of pain and subjective symptoms of myofascial pain syndrome.